Pub. Date : 2015 Jan 28
PMID : 25626693
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |
| 2 | Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |
| 3 | Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |
| 4 | Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |
| 5 | The neo-synthesis of Asn by asparagine synthetase (AsnS) following ASNase treatment, which involves the amino acid response and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways, is believed to be the basis of ASNase-resistance mechanisms. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |
| 6 | The neo-synthesis of Asn by asparagine synthetase (AsnS) following ASNase treatment, which involves the amino acid response and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways, is believed to be the basis of ASNase-resistance mechanisms. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |
| 7 | The aim of this study was to identify possible ASNase sensitivity/resistance-related genes or pathways using a new asparaginase, namely a pegylated r-crisantaspase, with a focus on classic Asn-compensatory responses and cell death under conditions of Asn/L-glutamine limitation. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |
| 8 | The response of malignant NK cell lines to ASNase may depend on Asn-compensatory mechanisms and other cellular processes such as cleavage of BCL2A1, a prosurvival member of the Bcl-2 protein family. | Asparagine | asparaginase and isoaspartyl peptidase 1 | Homo sapiens |