Title : Methylglyoxal activates the target of rapamycin complex 2-protein kinase C signaling pathway in Saccharomyces cerevisiae.

Pub. Date : 2015 Apr

PMID : 25624345






3 Functional Relationships(s)
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1 We show here that methylglyoxal activates the Pkc1-Mpk1 mitogen-activated protein (MAP) kinase cascade in a target of rapamycin complex 2 (TORC2)-dependent manner in the budding yeast Saccharomyces cerevisiae. Pyruvaldehyde CREB regulated transcription coactivator 2 Homo sapiens
2 Methylglyoxal activated mammalian TORC2 signaling, which, in turn, phosphorylated Akt at Ser(473). Pyruvaldehyde CREB regulated transcription coactivator 2 Homo sapiens
3 Our results suggest that methylglyoxal is a conserved initiator of TORC2 signaling among eukaryotes. Pyruvaldehyde CREB regulated transcription coactivator 2 Homo sapiens