Pub. Date : 2014 Dec
PMID : 25623760
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | OBJECTIVE: To observe the impact of concurrent administration of recombinant human p53 adenovirus (Ad-p53) with EGFR inhibitor gefitinib on breast cancer MDA-MB-468 cells. | Gefitinib | tumor protein p53 | Homo sapiens |
2 | OBJECTIVE: To observe the impact of concurrent administration of recombinant human p53 adenovirus (Ad-p53) with EGFR inhibitor gefitinib on breast cancer MDA-MB-468 cells. | Gefitinib | tumor protein p53 | Homo sapiens |
3 | RESULTS: The MTT assay showed a stronger inhibitory effect of gefitinib on MDA-MB-468 cells infected with Ad-p53 than on the control cells. | Gefitinib | tumor protein p53 | Homo sapiens |
4 | CONCLUSIONS: Wild-type p53 may reverse the sensitivity of MDA-MB-468 cells to gefitinib through down-regulation of the PI3K/Akt pathway. | Gefitinib | tumor protein p53 | Homo sapiens |