Title : [Effect of recombinant human p53 adenovirus (Ad-p53) combined with EGFR inhibitor gefitinib on the sensitivity of breast cancer MDA-MB-468 cells].

Pub. Date : 2014 Dec

PMID : 25623760






4 Functional Relationships(s)
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1 OBJECTIVE: To observe the impact of concurrent administration of recombinant human p53 adenovirus (Ad-p53) with EGFR inhibitor gefitinib on breast cancer MDA-MB-468 cells. Gefitinib tumor protein p53 Homo sapiens
2 OBJECTIVE: To observe the impact of concurrent administration of recombinant human p53 adenovirus (Ad-p53) with EGFR inhibitor gefitinib on breast cancer MDA-MB-468 cells. Gefitinib tumor protein p53 Homo sapiens
3 RESULTS: The MTT assay showed a stronger inhibitory effect of gefitinib on MDA-MB-468 cells infected with Ad-p53 than on the control cells. Gefitinib tumor protein p53 Homo sapiens
4 CONCLUSIONS: Wild-type p53 may reverse the sensitivity of MDA-MB-468 cells to gefitinib through down-regulation of the PI3K/Akt pathway. Gefitinib tumor protein p53 Homo sapiens