Pub. Date : 2014 Nov
PMID : 25620256
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [MicroRNA-210 mediates the protective effect of rosuvastatin on human mesenchymal stem cells apoptosis induced by tumor necrosis factor-alpha]. | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 2 | OBJECTIVE: To explore the effect and mechanism of rosuvastatin on tumor necrosis factor-alpha induced human mesenchymal stem cells (MSCs) apoptosis. | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 3 | RESULT: TNF-alpha significantly induced human MSCs apoptosis in a concentration-dependent manner, and pretreatment with rosuvastatin significantly reduced MSCs apoptosis (caspase-3 assay: TNF-alpha+Statin group vs. TNF-alpha group: (1.63 +- 0.25) vs. (2.05 +- 0.36), P < 0.05). | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 4 | RESULT: TNF-alpha significantly induced human MSCs apoptosis in a concentration-dependent manner, and pretreatment with rosuvastatin significantly reduced MSCs apoptosis (caspase-3 assay: TNF-alpha+Statin group vs. TNF-alpha group: (1.63 +- 0.25) vs. (2.05 +- 0.36), P < 0.05). | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 5 | The protective effect of rosuvastatin on TNF-alpha induced MSCs apoptosis was largely abolished by co-treatment with 100 nmol/L antago-miRNA (TUNEL:TNF-alpha + Statin + antago-miR group vs. TNF-alpha + Statin group: (42.58 +- 6.71) % vs. (16.87 +- 9.27) %, P < 0.05). | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 6 | The protective effect of rosuvastatin on TNF-alpha induced MSCs apoptosis was largely abolished by co-treatment with 100 nmol/L antago-miRNA (TUNEL:TNF-alpha + Statin + antago-miR group vs. TNF-alpha + Statin group: (42.58 +- 6.71) % vs. (16.87 +- 9.27) %, P < 0.05). | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 7 | The protective effect of rosuvastatin on TNF-alpha induced MSCs apoptosis was largely abolished by co-treatment with 100 nmol/L antago-miRNA (TUNEL:TNF-alpha + Statin + antago-miR group vs. TNF-alpha + Statin group: (42.58 +- 6.71) % vs. (16.87 +- 9.27) %, P < 0.05). | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 8 | CONCLUSION: Pretreatment with rosuvastatin can significantly improve the viability of human MSCs after TNF-alpha injury, the protective mechanism of rosuvastatin is partly mediated through miRNA-210 up-regulation. | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |
| 9 | CONCLUSION: Pretreatment with rosuvastatin can significantly improve the viability of human MSCs after TNF-alpha injury, the protective mechanism of rosuvastatin is partly mediated through miRNA-210 up-regulation. | Rosuvastatin Calcium | tumor necrosis factor | Homo sapiens |