Pub. Date : 2015 Feb 20
PMID : 25613864
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, glutamine has been shown to alter mTORC1 activity in a TSC1-TSC2 independent manner in cells cultured under amino acid- and serum-deprived conditions. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Since starvation culture conditions are not physiologically relevant, we examined if glutamine can regulate mTORC1 in non-deprived cells and in a murine model of TSC. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Our results show that glutamine can reduce phosphorylation of S6 and S6 kinase, surrogate indicators of mTORC1 activity, in both deprived and non-deprived cells, although higher concentrations were required for non-deprived cultures. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |