Pub. Date : 2015
PMID : 25613518
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. | 7,3'-dihydroxy-4'-methoxyisoflavone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR. | 7,3'-dihydroxy-4'-methoxyisoflavone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSION: Calycosin is more effective in inhibiting breast cancer growth in comparison with genistein, through its regulation of Akt signaling pathways and HOTAIR expression. | 7,3'-dihydroxy-4'-methoxyisoflavone | AKT serine/threonine kinase 1 | Homo sapiens |