Title : IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population.

Pub. Date : 2014 Dec

PMID : 25606440






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The tyrosine phosphorylation of IRS1 serves as docking molecules for downstream effectors such as Phosphatidylinositol 3-kinase and phosphotyrosine phosphatase-2. Tyrosine insulin receptor substrate 1 Homo sapiens
2 We focused on the Gly972Arg and Ala513Pro variants of the IRS1 gene, since these specific allelic variants are located near the Tyr-Met-X-Met (YMXM) motifs around Tyr987 and Tyr612. Tyrosine insulin receptor substrate 1 Homo sapiens