Title : Variations in the Blood Phenytoin Levels during Long-Term Combined Treatment with S-1 and Phenytoin.

Pub. Date : 2014 Sep-Dec

PMID : 25606031






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1 Although combination therapy with the oral fluoropyrimidine anticancer drug S-1 and the anticonvulsant phenytoin (PHT) is known to increase blood levels of PHT and the risk of intoxication, reports on long-term monitoring of blood levels of PHT during combined S-1 and PHT treatment and a thorough understanding of their interaction are lacking. 2-fluoropyrimidine proteasome 26S subunit, non-ATPase 1 Homo sapiens