Pub. Date : 2015 Jan 20
PMID : 25601475
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VAD modulates chromatin structure in cis and activates gene expression in trans at the INK4 locus, which encodes cell cycle inhibitors important for senescence-associated cell proliferation arrest. | VAD I protocol | cyclin dependent kinase inhibitor 2A | Homo sapiens |
| 2 | Importantly, VAD inhibits the incorporation of the repressive histone variant H2A.Z at INK4 gene promoters in senescent cells. | VAD I protocol | cyclin dependent kinase inhibitor 2A | Homo sapiens |