Title : A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.

Pub. Date : 2015 Apr

PMID : 25595597






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement. 3-hydroxydesloratadine UDP glucuronosyltransferase family 2 member B10 Homo sapiens
2 Overall, our results demonstrate for the first time that desloratadine glucuronidation by UGT2B10 followed by CYP2C8 oxidation and a deconjugation event are responsible for the formation of 3-hydroxydesloratadine. 3-hydroxydesloratadine UDP glucuronosyltransferase family 2 member B10 Homo sapiens