Pub. Date : 2015 Jul 15
PMID : 25593096
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potency enhancement of the kappa-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif. | 1,2,3,4-tetrahydroisoquinoline | opioid receptor kappa 1 | Homo sapiens |
| 2 | Optimization of the sulfonamide-based kappa opioid receptor (KOR) antagonist probe molecule ML140 through constraint of the sulfonamide nitrogen within a tetrahydroisoquinoline moiety afforded a marked increase in potency. | 1,2,3,4-tetrahydroisoquinoline | opioid receptor kappa 1 | Homo sapiens |
| 3 | Optimization of the sulfonamide-based kappa opioid receptor (KOR) antagonist probe molecule ML140 through constraint of the sulfonamide nitrogen within a tetrahydroisoquinoline moiety afforded a marked increase in potency. | 1,2,3,4-tetrahydroisoquinoline | opioid receptor kappa 1 | Homo sapiens |