Title : Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.

Pub. Date : 2015 Jul 15

PMID : 25593096






1 Functional Relationships(s)
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1 This strategy, when combined with additional structure-activity relationship exploration, has led to a compound only six-fold less potent than norBNI, a widely utilized KOR antagonist tool compound, but significantly more synthetically accessible. norbinaltorphimine opioid receptor kappa 1 Homo sapiens