Pub. Date : 2015 Jan 15
PMID : 25593029
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of intracellular calcium mobilization in IL-8 activation in human retinal pigment epithelial cells. | Calcium | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | The purpose of this study is to understand the molecular mechanisms by which calcium signaling controls IL-8 activation in human RPE cells. | Calcium | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | RESULTS: Our study reported that intracellular calcium mobilization activated IL-8 gene expression and secretion. | Calcium | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Application of pharmacological inhibitor BAY 11-7082, siRNA, and plasmids of the nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) binding site, we identified that NF-kappaB is the main transcription factor involved in intracellular calcium mobilization-mediated IL-8 activation in human RPE cells. | Calcium | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | CONCLUSIONS: Collectively, our findings highlight the important role of intracellular calcium mobilization in the activation of IL-8. | Calcium | C-X-C motif chemokine ligand 8 | Homo sapiens |