Title : Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis.

Pub. Date : 2015 Jul

PMID : 25585625

1 Functional Relationships(s)
Compound Name
Protein Name
1 We demonstrate that IL-1beta-treated GPR40(-/-) chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40(+/+) cells. Dinoprostone interleukin 1 beta Mus musculus