Title : Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing.

Pub. Date : 2015 Jan 22

PMID : 25579209






1 Functional Relationships(s)
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1 These results validate XPO1 as the prime target of selinexor in cells and identify the selectivity of this drug toward the cysteine 528 residue of XPO1. Cysteine exportin 1 Homo sapiens