Title : Novobiocin and peptide analogs of α-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p.

Pub. Date : 2015 Apr

PMID : 25576192






2 Functional Relationships(s)
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1 Novobiocin and peptide analogs of alpha-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p. Novobiocin alpha-factor pheromone receptor STE2 Saccharomyces cerevisiae S288C
2 Immunoblots probing for the Ste2p-[Bio-DOPA]11-mer complex revealed that novobiocin markedly decreased cross-linking of the [Bio-DOPA]11-mer to the receptor, but cross-linking of the alpha-factor analog [Bio-DOPA]13-mer, which interacts with the orthosteric binding site of the receptor, was minimally altered. Novobiocin alpha-factor pheromone receptor STE2 Saccharomyces cerevisiae S288C