Pub. Date : 2015 Feb
PMID : 25572805
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The possible TAMs-modulated drug resistance mechanism involved may be associated with elevation of bcl-2 gene expression and up-regulation of STAT3 signaling in tumor cells. | tams | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Furthermore, the blockage of TAMs-derived IL-10 by neutralizing antibody resulted in attenuation of STAT3 activation and decrease of bcl-2 mRNA expression, consequently enhanced sensitivity of breast cancer cells. | tams | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Our data suggested that TAMs might induce drug resistance through IL-10/STAT3/bcl-2 signaling pathway, providing possible new targets for breast tumor therapy. | tams | signal transducer and activator of transcription 3 | Homo sapiens |