Title : The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the β-tent fold.

Pub. Date : 2015 Jan

PMID : 25569776






2 Functional Relationships(s)
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Protein Name
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1 The protein cereblon, which forms an E3 ubiquitin ligase compex together with damaged DNA-binding protein 1 (DDB1) and cullin 4A, has been recently indentified as a primary target of thalidomide and its C-terminal part as responsible for binding thalidomide within a domain carrying several invariant cysteine and tryptophan residues. Thalidomide damage specific DNA binding protein 1 Homo sapiens
2 The protein cereblon, which forms an E3 ubiquitin ligase compex together with damaged DNA-binding protein 1 (DDB1) and cullin 4A, has been recently indentified as a primary target of thalidomide and its C-terminal part as responsible for binding thalidomide within a domain carrying several invariant cysteine and tryptophan residues. Thalidomide damage specific DNA binding protein 1 Homo sapiens