Title : Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus-Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia.

Pub. Date : 2015 Sep

PMID : 25569182






1 Functional Relationships(s)
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1 We found that blocking the binding of ligand using suramin or monoclonal IMC-3G3 antibody significantly reduced ligand-induced autophosphorylation of Y1009 without affecting ligand-independent transphosphorylation of Y934 residue on PDGFRbeta in human pulmonary arterial SMCs treated with both cocaine and Tat. Suramin platelet derived growth factor receptor beta Homo sapiens