Title : Intravenous alprazolam challenge in normal subjects. Biochemical, cardiovascular, and behavioral effects.

Pub. Date : 1989

PMID : 2556727






4 Functional Relationships(s)
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1 Alprazolam reduced ACTH and cortisol while increasing growth hormone. Alprazolam growth hormone 1 Homo sapiens
2 This pharmacodynamic profile resembles that previously reported for traditional benzodiazepines, although alprazolam may be a more potent stimulator of growth hormone release. Alprazolam growth hormone 1 Homo sapiens
3 Alprazolam"s effects on growth hormone resemble those of clonidine, but unlike clonidine, alprazolam has relatively little effect on plasma catecholamine and cardiovascular parameters. Alprazolam growth hormone 1 Homo sapiens
4 Since alprazolam infusion affects three different measures (ACTH/cortisol, growth hormone, and plasma norepinephrine) thought to be dysregulated in depression, challenge with intravenous alprazolam may prove to be a useful "probe" in affective disorders. Alprazolam growth hormone 1 Homo sapiens