Title : Additive Suppression of LPS-Induced IL-10 and TNF-α by Pre-treatment of Dexamethasone and SB203580 in a Murine Alveolar Macrophage Cell Line (MH-S).

Pub. Date : 2015

PMID : 25563207






2 Functional Relationships(s)
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1 Pre-treatment of DEX or SB203580 inhibited lipopolysaccharide (LPS)-stimulated IL-10, TNF-alpha secretion, and STAT3 phosphorylation. Dexamethasone signal transducer and activator of transcription 3 Mus musculus
2 Combining DEX and SB203580 showed strong inhibition on the LPS-induced IL-10 secretion and STAT3 phosphorylation, which might reflect a very important drawback from the combined use of both anti-inflammatory agents. Dexamethasone signal transducer and activator of transcription 3 Mus musculus