Title : CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.

Pub. Date : 2015 Jan 22

PMID : 25557551






1 Functional Relationships(s)
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1 Here we show that all three TET proteins bind to VprBP and are monoubiquitylated by the VprBP-DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue. tetramethylenedisulfotetramine interleukin 17 receptor B Homo sapiens