Title : Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1.

Pub. Date : 2015 Feb

PMID : 25557114






2 Functional Relationships(s)
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1 Furthermore, sorafenib (2-6 mumol/L) dose-dependently decreased the expression of FoxM1, MMP-2, and Ki-67, and up-regulated that of p53 in the cells. Sorafenib matrix metallopeptidase 2 Homo sapiens
2 CONCLUSION: Sorafenib inhibits HCC proliferation and invasion by inhibiting MMP-2 and Ki-67 expression due to up-regulation of P53 and suppressing FoxM1. Sorafenib matrix metallopeptidase 2 Homo sapiens