Title : Low intracellular iron increases the stability of matriptase-2.

Pub. Date : 2015 Feb 13

PMID : 25550162






5 Functional Relationships(s)
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1 Low intracellular iron increases the stability of matriptase-2. Iron transmembrane serine protease 6 Homo sapiens
2 Here, we report that MT2 is up-regulated under iron deprivation. Iron transmembrane serine protease 6 Homo sapiens
3 Rather, studies using a membrane-permeable iron chelator, salicylaldehyde isonicotinoyl hydrazone, revealed that depletion of cellular iron was able to decrease the degradation of MT2 independently of internalization. Iron transmembrane serine protease 6 Homo sapiens
4 Rather, studies using a membrane-permeable iron chelator, salicylaldehyde isonicotinoyl hydrazone, revealed that depletion of cellular iron was able to decrease the degradation of MT2 independently of internalization. Iron transmembrane serine protease 6 Homo sapiens
5 We found that lack of the putative endocytosis motif in its cytoplasmic domain largely abolished the sensitivity of MT2 to iron depletion. Iron transmembrane serine protease 6 Homo sapiens