Title : Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium.

Pub. Date : 2015 May

PMID : 25546398






2 Functional Relationships(s)
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1 Macrophages exposed to GL-CM presented decreased ATP and AMP hydrolysis and increased IL-10 and MCP-1 secretion, effects that were diminished by P1 or P2 antagonists. glycylleucine C-C motif chemokine ligand 2 Homo sapiens
2 In summary, we found that A2A and P2X7 activation is necessary for IL-10, MCP-1, and IL-6 release by macrophages exposed to GL-CM, which, in turn, modulates the macrophages to M2-phenotype. glycylleucine C-C motif chemokine ligand 2 Homo sapiens