Title : Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma.

Pub. Date : 2015 Feb 10

PMID : 25544770






1 Functional Relationships(s)
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1 Pancreatic cell lines treated with Gem and PX-478 can induce an increase in eIF2alpha phosphorylation was correlated with down-regulation of HIF-1alpha and elicited exposure of CRT and release of HMGB1 and ATP. 2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide eukaryotic translation initiation factor 2A Mus musculus