Title : Neuroendocrine evidence of deranged noradrenergic activity in chronic migraine.

Pub. Date : 1989

PMID : 2554358






4 Functional Relationships(s)
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1 In order to elucidate the relationship between noradrenergic and opioidergic functions, the plasma beta-endorphin (beta-EP) response to clonidine and the cortisol response to dexamethasone were evaluated together in 25 patients suffering from migraine without aura, and with chronic tension headache (MTH). Clonidine proopiomelanocortin Homo sapiens
2 In order to elucidate the relationship between noradrenergic and opioidergic functions, the plasma beta-endorphin (beta-EP) response to clonidine and the cortisol response to dexamethasone were evaluated together in 25 patients suffering from migraine without aura, and with chronic tension headache (MTH). Clonidine proopiomelanocortin Homo sapiens
3 Baseline beta-EP plasma levels and beta-EP response to clonidine were significantly lower in MTH subjects than in controls, suggesting a postsynaptic hypothalamo-pituitary impairment. Clonidine proopiomelanocortin Homo sapiens
4 An inverse correlation was found between pain severity and beta-EP secretion induced by clonidine (delta max), and no relationship was found between beta-EP and mood. Clonidine proopiomelanocortin Homo sapiens