Title : Pifithrin-α ameliorates resveratrol-induced two-cell block in mouse preimplantation embryos in vitro.

Pub. Date : 2015 Mar 15

PMID : 25542456






2 Functional Relationships(s)
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1 Resveratrol was found to significantly increase the expressions of p53, p21, Atf3, smac/Diablo, Bax, Bak1, Bok, and Noxa mRNA in the embryos, whereas Cullin 3 and Cdk1 expressions were decreased. Resveratrol transformation related protein 53, pseudogene Mus musculus
2 Pretreatment with pifithrin-alpha, a p53 inhibitor, downregulated active p53 in two-cell embryo nuclei and ameliorated approximately 50% of the embryonic developmental defect caused by resveratrol. Resveratrol transformation related protein 53, pseudogene Mus musculus