Pub. Date : 2015 Aug 1
PMID : 25530422
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we demonstrate that the proteasome inhibitor Bortezomib strongly inhibits ERalpha and HER2/neu expression, increases expression of cyclin-dependent kinase inhibitors, inhibits expression of multiple genes associated with poor prognosis in ERalpha+ breast cancer patients and induces cell death in ER+ breast cancer cells in both the presence and absence of functional p53. | Bortezomib | tumor protein p53 | Homo sapiens |
| 2 | Although Bortezomib increased the levels of p53 and increased the expression of pro-apoptotic target genes in ERalpha+ breast cancer cells harboring wild-type p53, Bortezomib also exerts anti-tumoral effects on ERalpha+ breast cancer cells through suppression of ERalpha expression and inhibition of PI3K/Akt/mammalian target of rapamycin (mTOR) and ERK signaling independently of functional p53. | Bortezomib | tumor protein p53 | Homo sapiens |