Title : Deletion of PHO13, encoding haloacid dehalogenase type IIA phosphatase, results in upregulation of the pentose phosphate pathway in Saccharomyces cerevisiae.

Pub. Date : 2015 Mar

PMID : 25527558






3 Functional Relationships(s)
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1 Transcriptome sequencing analysis revealed that pho13Delta resulted in upregulation of the pentose phosphate (PP) pathway and NADPH-producing enzymes when cells were grown on glucose or xylose. NADP 4-nitrophenylphosphatase Saccharomyces cerevisiae S288C
2 We also found that the transcriptional changes induced by pho13Delta required the transcription factor Stb5, which is activated specifically under NADPH-limiting conditions. NADP 4-nitrophenylphosphatase Saccharomyces cerevisiae S288C
3 Thus, pho13Delta resulted in the upregulation of the PP pathway and NADPH-producing enzymes as a part of an oxidative stress response mediated by activation of Stb5. NADP 4-nitrophenylphosphatase Saccharomyces cerevisiae S288C