Pub. Date : 2015 May
PMID : 25521189
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells. | Dexrazoxane | activating transcription factor 3 | Homo sapiens |
| 2 | EXPERIMENTAL APPROACH: We investigated the DNA damage response and the role of the activating transcription factor 3 (ATF3) accumulation in tumour cells exposed to dexrazoxane. | Dexrazoxane | activating transcription factor 3 | Homo sapiens |
| 3 | EXPERIMENTAL APPROACH: We investigated the DNA damage response and the role of the activating transcription factor 3 (ATF3) accumulation in tumour cells exposed to dexrazoxane. | Dexrazoxane | activating transcription factor 3 | Homo sapiens |
| 4 | ATF3 protein was induced by dexrazoxane in a concentration- and time-dependent manner, which was abolished in TOP2A-depleted cells and in cells pre-incubated with ATM inhibitor. | Dexrazoxane | activating transcription factor 3 | Homo sapiens |
| 5 | Knockdown of ATF3 gene expression by siRNA triggered apoptosis in control cells and diminished the p53 protein level in both control and dexrazoxane -treated cells. | Dexrazoxane | activating transcription factor 3 | Homo sapiens |
| 6 | ATF3 knockdown also delayed the repair of dexrazoxane -induced DNA double-strand breaks. | Dexrazoxane | activating transcription factor 3 | Homo sapiens |
| 7 | The DNA damage-triggered ATF3 controlled p53 accumulation and generation of double-strand breaks and is proposed to serve as a switch between DNA damage and cell death following dexrazoxane treatment. | Dexrazoxane | activating transcription factor 3 | Homo sapiens |