Title : Nicotine facilitates reinnervation of phenol-injured perivascular adrenergic nerves in the rat mesenteric resistance artery.

Pub. Date : 2015 Feb 5

PMID : 25514605






2 Functional Relationships(s)
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1 A pretreatment with nicotinic acetylcholine receptor antagonists hexamethonium, mecamylamine, and methyllycaconitine, but not dextrometorphan, canceled the TH-LI nerve reinnervation induced by nicotine. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
2 These results suggested that nicotine exhibited neurotrophic effects that facilitated the reinnervation of adrenergic TH-LI nerves by activating alpha7 nicotinic acetylcholine receptor and NGF in the SCG. Nicotine cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus