Title : STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models.

Pub. Date : 2014 Dec 30

PMID : 25512545






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we show that the expression of Stat3 is increased in PRs of the Tg(RHO P347S) and Prph2(rds) (/+) mouse models of IPD and is activated by tyrosine phosphorylation. Tyrosine signal transducer and activator of transcription 3 Mus musculus
2 Phosphorylation of STAT3 at tyrosine 705 was required for the prosurvival effect because an R26-Stat3(Y705F) allele was not protective. Tyrosine signal transducer and activator of transcription 3 Mus musculus