Title : Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib.

Pub. Date : 2015 Feb

PMID : 25501339






2 Functional Relationships(s)
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1 Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib. Gefitinib tumor protein p53 Homo sapiens
2 Importantly, wild-type p53 was able to reverse the drug resistance of MDA-MB-468 cells to gefitinib through inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Gefitinib tumor protein p53 Homo sapiens