Title : Nanoparticle-mediated dual delivery of an antioxidant and a peptide against the L-Type Ca2+ channel enables simultaneous reduction of cardiac ischemia-reperfusion injury.

Pub. Date : 2015 Jan 27

PMID : 25493575






1 Functional Relationships(s)
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1 Simultaneous delivery of the AID peptide with curcumin allowed for effective attenuation of the L-type Ca(2+) channel-activated increases in superoxide (assessed as changes in DHE fluorescence; Empty NP = 53.1 +- 7.6%; NP-C-AID = 7.32 +- 3.57%) and mitochondrial membrane potential (assessed as changes in JC-1 fluorescence; Empty NP = 19.8 +- 2.8%; NP-C-AID=13.05 +- 1.78%). Superoxides activation-induced cytidine deaminase Rattus norvegicus