Title : Molecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases.

Pub. Date : 2015 Jan 20

PMID : 25489790

2 Functional Relationships(s)
Compound Name
Protein Name
1 Many of the active site residues are conserved between the CTX-M family and non-ESBL beta-lactamases such as TEM-1, but the residues Ser237 and Arg276 are specific to the CTX-M family, suggesting that they may help to define the increased specificity for cefotaxime hydrolysis. Cefotaxime CD248 molecule Homo sapiens
2 Substitutions of Ser237 and Arg276 with their TEM-1 counterparts, Ala237 and Asn276, had a modest effect on cefotaxime hydrolysis, as did removal of the Arg276 side chain in an R276A mutant. Cefotaxime CD248 molecule Homo sapiens