Pub. Date : 2015 Jan
PMID : 25487445
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2alpha/COX-2. | Sorafenib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | In conclusion, our results demonstrated that hypoxia promoted the invasiveness and resistance of 786-O cells to sorafenib via HIF2 and COX-2 and induced the activation of Snail/E-cadherin, suggesting that a signalling mechanism involving HIF2/COX2 modulates invasiveness and resistance to sorafenib in 786-O cells under hypoxia. | Sorafenib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |