Title : DNA end resection is needed for the repair of complex lesions in G1-phase human cells.

Pub. Date : 2014

PMID : 25486192






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Resection of complex DSBs is driven by meiotic recombination 11 homolog A (MRE11), CTBP-interacting protein (CtIP), and exonuclease 1 (EXO1) but seems not controlled by the Ku heterodimer or by phosphorylation of H2AX. dsbs RB binding protein 8, endonuclease Homo sapiens
2 Resection of complex DSBs is driven by meiotic recombination 11 homolog A (MRE11), CTBP-interacting protein (CtIP), and exonuclease 1 (EXO1) but seems not controlled by the Ku heterodimer or by phosphorylation of H2AX. dsbs RB binding protein 8, endonuclease Homo sapiens
3 Reduced resection capacity by CtIP depletion increased cell killing and the fraction of unrepaired DSBs after exposure to densely ionizing heavy ions, but not to X-rays. dsbs RB binding protein 8, endonuclease Homo sapiens