Title : ZNF300 knockdown inhibits forced megakaryocytic differentiation by phorbol and erythrocytic differentiation by arabinofuranosyl cytidine in K562 cells.

Pub. Date : 2014

PMID : 25485965






3 Functional Relationships(s)
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1 We found that ZNF300 upregulation in K562 cells coincided with megakaryocytic differentiation induced by phorbol-12-myristate-13-acetate (PMA) or erythrocytic differentiation induced by cytosine arabinoside (Ara-C), respectively. Tetradecanoylphorbol Acetate zinc finger protein 300 Homo sapiens
2 We found that ZNF300 upregulation in K562 cells coincided with megakaryocytic differentiation induced by phorbol-12-myristate-13-acetate (PMA) or erythrocytic differentiation induced by cytosine arabinoside (Ara-C), respectively. Tetradecanoylphorbol Acetate zinc finger protein 300 Homo sapiens
3 To further test whether ZNF300 upregulation promoted differentiation, we knocked down ZNF300 and found that ZNF300 knockdown effectively abolished PMA-induced megakaryocytic differentiation, evidenced by decreased CD61 expression. Tetradecanoylphorbol Acetate zinc finger protein 300 Homo sapiens