Title : Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia.

Pub. Date : 2015 Feb

PMID : 25485537






2 Functional Relationships(s)
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1 After inactivating Notch signal by DAPT, Th17 cells and Th17/Treg ratio were dose dependently decreased and accompanied by the reduction of IL-17 in culture supernatants and RORgammat mRNA expression in ITP patients. dapt interleukin 17A Homo sapiens
2 We also present evidence that the effect of DAPT inhibition on the Th17 cell response was associated with downregulation of RORgammat and IL-17 transcription using human in vitro polarization. dapt interleukin 17A Homo sapiens