Title : The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology.

Pub. Date : 2015 Jan

PMID : 25470336






3 Functional Relationships(s)
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Protein Name
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1 The gamma-amino butyric acid (GABA) synthetic enzyme glutamic acid decarboxylase (GAD)65 is critically involved in the activity-dependent regulation of GABAergic inhibition in the central nervous system. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
2 The gamma-amino butyric acid (GABA) synthetic enzyme glutamic acid decarboxylase (GAD)65 is critically involved in the activity-dependent regulation of GABAergic inhibition in the central nervous system. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
3 In fact, we could recently show that GAD65 haplodeficiency, which results in delayed postnatal increase of GABA levels, provides resilience to juvenile-stress-induced anxiety to GAD65(+/-) mice thus foiling the increased fear and anxiety in homozygous GAD65(-/-) mice. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus