Pub. Date : 2014 Nov 28
PMID : 25469035
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results showed that treatment with 17beta-estradiol and/or ER agonists in human LoVo colorectal cancer cells activated p53 and then up-regulated p21 and p27 protein levels, subsequently inhibiting the downstream target gene, cyclin D1, which regulates cell proliferation. | Estradiol | tumor protein p53 | Homo sapiens |
| 2 | These results demonstrate that 17beta-estradiol and/or ER agonists downregulate migration-related proteins through the p53 signaling pathway in human LoVo colorectal cancer cells. | Estradiol | tumor protein p53 | Homo sapiens |
| 3 | These findings suggest that p53 plays a critical role in the 17beta-estradiol and/or ER agonist-mediated protective activity against colorectal cancer progression. | Estradiol | tumor protein p53 | Homo sapiens |