Title : Effects of pretreatment with tetradecanoyl phorbol acetate on regulation of growth hormone and prolactin secretion from ovine anterior pituitary cells.

Pub. Date : 1989 Jul 17

PMID : 2546831






6 Functional Relationships(s)
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1 Effects of pretreatment with tetradecanoyl phorbol acetate on regulation of growth hormone and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate growth hormone 1 Homo sapiens
2 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate growth hormone 1 Homo sapiens
3 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate growth hormone 1 Homo sapiens
4 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate growth hormone 1 Homo sapiens
5 Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells. Tetradecanoylphorbol Acetate growth hormone 1 Homo sapiens
6 Pretreatment of the cells with TPA abolishes this effect, presumably due to down-regulation of protein kinase C. Such pretreatment did not alter effects of thyrotropin-releasing hormone or dopamine on prolactin secretion, suggesting no involvement of protein kinase C. Pretreatment with TPA attenuated actions of GH-releasing hormone on GH release (but not actions on cyclic AMP levels), possibly due to depletion of cellular stores of GH. Tetradecanoylphorbol Acetate growth hormone 1 Homo sapiens