Title : Benzodiazepine-dependent stabilization of GABA(A) receptors at synapses.

Pub. Date : 2014 Nov

PMID : 25466558






2 Functional Relationships(s)
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1 Surprisingly, the positive allosteric modulator diazepam abolished the regulation induced by muscimol, and this effect was observed on alpha1, alpha2, alpha5 and gamma2 GABA(A)R subunits. Diazepam gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
2 Altogether these results indicate that diazepam stabilizes synaptic GABA(A)Rs and thus prevents the agonist-induced regulation of GABA(A)R levels at synapses. Diazepam gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus