Title : Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.

Pub. Date : 2014 Dec 15

PMID : 25466173






1 Functional Relationships(s)
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1 This Letter describes the on-going SAR efforts based on two scaffolds, a PLD1-biased piperidinyl benzimidazolone and a PLD2-biased piperidinyl triazaspirone, with the goal of enhancing PLD inhibitory potency and isoform selectivity. piperidinyl benzimidazolone phospholipase D1 Homo sapiens