Title : Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors.

Pub. Date : 2015 Jan-Feb

PMID : 25464020






2 Functional Relationships(s)
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1 RESULTS: Direct enzymatic activity assay revealed significant and concentration-dependent inhibition effect of vildagliptin, saxagliptin on DPP8/9. Vildagliptin dipeptidyl peptidase 8 Homo sapiens
2 Extracellular incubation of DPP8/9 over expressed cells with sitagliptin, vildagliptin, saxagliptin, alogliptin and linagliptin, showed only mild inhibition on DPP8/9. Vildagliptin dipeptidyl peptidase 8 Homo sapiens