Title : Engineering β1,4-galactosyltransferase I to reduce secretion and enhance N-glycan elongation in insect cells.

Pub. Date : 2015 Jan 10

PMID : 25462875






2 Functional Relationships(s)
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1 The results demonstrated a correlation between the levels of intracellular B4GALT1 activity and terminally galactosylated N-glycans, N-glycan branching, the appearance of hybrid structures, and reduced core fucosylation. n-glycan beta-1,4-galactosyltransferase 1 Homo sapiens
2 Thus, engineering B4GALT1 to reduce its cleavage and secretion is an approach that can be used to enhance N-glycan elongation in insect cells. n-glycan beta-1,4-galactosyltransferase 1 Homo sapiens