Title : Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors.

Pub. Date : 2014 Dec

PMID : 25455223






1 Functional Relationships(s)
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1 The proposed MOA consists of an initial effect on the liver by activating the constitutive androstane (Car) and pregnane X (Pxr) nuclear receptors causing increased elimination of thyroid hormones followed by an increased secretion of thyroid stimulating hormone (TSH). Pregnanes nuclear receptor subfamily 1, group I, member 2 Mus musculus