Title : Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.

Pub. Date : 2015 Feb

PMID : 25451639






1 Functional Relationships(s)
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1 Incubation of Gch1(fl/fl)Tie2cre macrophages with dihydroethidium revealed significantly increased production of superoxide in the presence of iNOS expression, and an iNOS-independent, BH4-dependent increase in other ROS species. Superoxides GTP cyclohydrolase 1 Mus musculus