Title : Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia.

Pub. Date : 2014 Nov 7

PMID : 25450364






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 ALAS2 is a mitochondrial enzyme, which utilizes glycine and succinyl-CoA to form 5-aminolevulinic acid (ALA), a crucial precursor in heme synthesis. Heme 5'-aminolevulinate synthase 2 Homo sapiens
2 Therefore, ALA supplementation could be an effective therapeutic strategy to restore heme synthesis in CSA caused by ALAS2 defects. Heme 5'-aminolevulinate synthase 2 Homo sapiens